NONMEM (Beal & Sheiner, 1992)
data entry format. Existing NONMEM files compatible. Extensive "on-line" documentation with hypertext.
Simple dialogue boxes and menu commands for model specification
Automated suggestions for vague priors and initial values. Correct handling of censored observations.
Full functionality of WinBUGS
available during and after analysis, e.g. diagnostic plots.
Extensive library of robustly parameterised PK model
components: 1, 2, or 3 compartments; intravenous, first-order, or
zero-order inputs (with lag-times); steady-state
equivalents for all models.
PK model library also accessible through WinBUGS,
for additional flexibility.
"Print model" option generates conciseWinBUGS
code for any PKBugs model -- allows the user almost unlimited flexibility.
code is easy to modify and/or restructure. Can incorporate, for example:
complex residual error structures; time-varying covariates; inter-occasion
variability (IOV) parameters (Karlsson & Sheiner, 1993;
Lunn & Aarons, 1997); and robust
distributions for handling outliers.
Windows 3.1x (requires Win32s), 95, 98, NT, 2000, XP.
Runs under WinBUGS
Version 1.3 -- registered/full version (free of charge) recommended.
No lower limit on RAM; however, MCMC analyses can generate a huge amount of information,
which WinBUGS stores
in RAM. 32Mb (or more) recommended.
No lower limit on processor. Pentium I (or higher) recommended.