Features & system requirements

Features

* NONMEM (Beal & Sheiner, 1992) data entry format. Existing NONMEM files compatible.
* Extensive "on-line" documentation with hypertext.
* Simple dialogue boxes and menu commands for model specification (point-and-click environment).
* Automated suggestions for vague priors and initial values.
* Correct handling of censored observations.
* Full functionality of WinBUGS available during and after analysis, e.g. diagnostic plots.
* Extensive library of robustly parameterised PK model components: 1, 2, or 3 compartments; intravenous, first-order, or zero-order inputs (with lag-times); steady-state equivalents for all models.
* PK model library also accessible through WinBUGS, for additional flexibility.
* "Print model" option generates concise WinBUGS code for any PKBugs model -- allows the user almost unlimited flexibility.
* Generated WinBUGS code is easy to modify and/or restructure. Can incorporate, for example: complex residual error structures; time-varying covariates; inter-occasion variability (IOV) parameters (Karlsson & Sheiner, 1993; Lunn & Aarons, 1997); and robust distributions for handling outliers.

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System requirements

* Windows 3.1x (requires Win32s), 95, 98, NT, 2000, XP.
* Runs under WinBUGS Version 1.3 -- registered/full version (free of charge) recommended.
* No lower limit on RAM; however, MCMC analyses can generate a huge amount of information, which WinBUGS stores in RAM. 32Mb (or more) recommended.
* No lower limit on processor. Pentium I (or higher) recommended.

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        Last Updated   December 2004

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Dave Lunn
MRC Biostatistics Unit,
Institute of Public Health,
University Forvie site,
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